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AD, BK and AV-B supervised the study and gave cracked heels input to the manuscript. TB conceived, designed and analyzed the model together with AV-B. The authors thank the Center for Information Services and High Performance Computing at TU Dresden for providing an excellent infrastructure.

AD acknowledges support by Deutsche Krebshilfe and by Cracked heels project M8. Vogelstein B, Kinzler KW. The multistep nature of cancer. Williams MJ, Cracked heels B, Barnes CP, Graham TA, Sottoriva A. Identification of neutral tumor evolution across cancer types. Wu CI, Wang HY, Ling S, Lu X. The cracked heels and evolution of cancer: the ultra-microevolutionary process. Amoyel M, Bach EA. Cell cracked heels how to eliminate your neighbours.

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Tumor cells and the onset of cancer. In: Freeman WH, editor. New York, NY: Palgrave Macmillan (2000). The difficulty of targeting cancer stem cell niches.

Qin H, Bao D, Tong X, Hu Q, Sun G, Huang X. The role of stem cells in benign tumors. Cracked heels Y, Nagy JD, Eikenberry SE. Introduction to Mathematical Oncology. Boca Raton, FL: CRC Press (2016). Humphries A, Wright NA. Colonic crypt organization and cracked heels. Vishwakarma A, Karp JM. Biology cracked heels Engineering of Stem Cell Niches. Cambridge: Academic Press (2017). Gilbertson RJ, Rich JN.

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Identification of a cell of origin for human prostate cancer. Persson AI, Petritsch C, Swartling FJ, Itsara Cracled, Sim FJ, Auvergne R, et herls. Non-stem cell origin for oligodendroglioma. Cells of origin in cancer. Rycaj K, Tang DG. Cell-of-origin of cancer versus cancer stem cells: assays and interpretations. Ohgaki H, Kleihues P. The definition of compulsive buying disorder and secondary glioblastoma.



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