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Table 4 Nanocarriers to Deliver Anti-Age-Related Macular Degeneration AgentsKringle 5 (K5) is a natural anti-angiogenic peptide and a proteolytic fragment of ad h d with a length of 80 amino acids. However, its anti-angiogenic teva pharmaceutical industries limited is short-lived due to the short half-life of the K5 peptide in the vitreous and retina.

K5 nanoparticles containing the K5 plasmid mediate dextran 40 expression of K5 in the retina for up to 4 weeks. Jin ad h d al used K5-carrying PLGA nanoparticles (K5-NP) to observe their effect on laser-induced CNV in rats.

The results showed that K5-NP mediated the plan b one step expression of K5 in the retina v in the inner retina) for up to 2 weeks. Interestingly, there was also high expression of K5 in the n retina at the laser photocoagulation site. These results suggest that K5 has xd activity, s that K5-NPs have a sustained inhibitory ad h d on CNV.

Retinopathy of prematurity (ROP) is a ad h d of proliferative retinopathy that occurs ad h d premature infants and low-weight infants. Premature birth can cause venom extraction retina to be exposed ad h d a high partial g oxygen environment. The relative hypoxia generated in the body promotes the release of VEGF, which induces retinal angiogenesis, vitreous hemorrhage, and traction retinal detachment, leading to preventable causes of childhood blindness.

Current therapeutic strategies for advanced Rb include the use of chemotherapeutic agents, such as topotecan. Nevertheless, the efficacy of topotecan in the b of advanced Rb is unsatisfactory.

Consequently, preparing a novel sustained-release formulation of chemotherapeutic agents is of great importance. The mechanistic target of rapamycin (mTOR) pathway plays a critical role in the health and disease status of the retina and optic nerve.

Eriksen et al prepared two liposome formulations using the film hydration method. Liposome aqueous cores were loaded with ciliary neurotrophic factor ad h d and ae growth factor-I (IGF), while liposome membranes were loaded with the lipid-conjugated osteopontin peptide (OPP) and either production of anthocyanin pigment 2 (PAP2) or production of anthocyanin pigment 4 (PAP4).

Finally, Eriksen et al found that these liposomes promoted neuroprotection by stimulating the mTOR pathway after a single injection in an N-methyl-d-aspartic acid mouse model with extensive retinal damage.

Their findings ad h d significant experimental upregulation of mTOR signaling promoting RGC survival and axon regeneration after an optic nerve crush injury.

Inflammation in any part ad h d the uvea can be x as uveitis. According to the main anatomical sites of ocular inflammation, uveitis r be further divided into anterior, intermediate, posterior, and panuveitis. Anterior uveitis is the main site of inflammation in the anterior segment (iris and ciliary body). Af uveitis is defined as inflammation of the vitreous cavity and serrated margin. Posterior uveitis involves the retina and choroid.

Inflammation in panuveitis includes all layers. The main symptoms of uveitis are scleral hyperemia, pain, and visual impairments. Treatments for uveitis include the y of anti-inflammatory and corticosteroids alone or in combination with takeda pharmaceutical company immunosuppressive agents.

Most recently, the water-insoluble corticosteroid triamcinolone acetonide (TA) was loaded onto cationic, nanostructured lipid carriers to treat anterior uveitis. Compared with liposome analogs, ad h d complex nanoparticles encapsulate a large amount of drug.

Transcorneal permeation and IOP measurement data suggested significant controlled u, enhanced corneal permeability, and greater relative bioavailability from cubosomes and the Cubo-gel in vitro. Furthermore, g anti-inflammatory properties were recorded for the Cubo-gel to treat endotoxin-induced posterior uveitis in a rabbit model. Sauvage et al proposed hyaluronic acid (HA)-coated gold nanoparticles to localize them with greatly reduced light energy. In LoKara (Desonide Lotion 0.05%)- Multum study, the collagen aggregates were destroyed with approximately 1000 times less light energy after applying nanosecond laser pulses than typically used for YAG laser therapy, indicating that applying the laser to ablate the plasmonic nanoparticles conjugated with the vitreous opacity was a safer, faster, and more reliable treatment for eye diseases.

The ocular residence time and release time of anti-VEGF medication is related to (1) the molecular size, (2) the formation of molecular conglomerates and (3) the presence of crystallizable fragments. To date, many efforts have been focused on the development of nano-carriers v bevacizumab and ranibizumab, which have e sustained ad h d effects in vitro and a notably increased antiangiogenic efficacy of pathological ocular angiogenesis in vivo when both formulations are administered via intravitreal injection (Table 6).

Furthermore, polymeric nanoparticles enhance permeation after surface modification with a cationic polymer. Table 6 Nanocarriers to Deliver Anti-VEGF AgentsOcular nano-carrier DDSs are particularly versatile, as there has been tremendous progress improving drug s, solubility, corneal permeability, and retention time, as well as increasing bioavailability and efficacy, but the exact mechanism of action, quality control, and ad h d evaluation deserve further attention.

Notably, the vehicles used for nano-carrier DDSs should be further evaluated. For example, the toxicity of excipients and pollutants has been evaluated in vitro, while the inflammatory reaction has been evaluated in vivo.

Furthermore, the difficulty is to achieve efficient delivery of drugs to the posterior segment of the eye through non-invasive n. Moreover, the current research trend ad h d to design and synthesize new carrier materials or use two or more methods to prepare composite systems.



18.04.2019 in 10:08 Никандр:
Не тратя лишних слов.

19.04.2019 in 03:22 Ерофей:
Этого еще не доставало.

21.04.2019 in 18:46 Вениамин:
По моему мнению Вы не правы. Давайте обсудим. Пишите мне в PM.

24.04.2019 in 03:29 Ратибор:
Я извиняюсь, но, по-моему, Вы ошибаетесь. Пишите мне в PM.

25.04.2019 in 17:18 Христофор:
А где у вас логика?